Goode, Alice; Butler, Kevin; Long, Jed; Cavey, James; Scott, Daniel; Shaw, Barry; Sollenberger, Jill; Gell, Christopher; Johansen, Terje; Oldham, Neil J.; Searle, Mark S.; Layfield, Robert (Journal article; Tidsskriftartikkel; Peer reviewed, 2016-05-12)
Growing evidence implicates impairment of autophagy as a candidate pathogenic mechanism in the
spectrum of neurodegenerative disorders which includes amyotrophic lateral sclerosis and frontotemporal
lobar degeneration (ALS-FTLD). SQSTM1, which encodes the autophagy receptor SQSTM1/p62, is genetically
associated with ALS-FTLD, although to date autophagy-relevant functional defects in disease-ass ...